DMG: A Nutrient for the New Millennium

DMG, short for dimethylglycine, is a nutritional supplement that can provide wonderful positive benefits to humans and animals. Our bodies use DMG every day, even though we don't know it. We produce DMG in small amounts, and it affects nearly every metabolic pathway within each cell of the body.

DMG is an adaptogen that works with other cofactors in the body to counteract the negative effects of stress, to promote healing and even to help prevent some degenerative diseases. Some of the things that it does are to decrease homocysteine levels (a risk factor for cardiovascular disease), increases oxygen utilization, modulates the immune response, aids in liver detoxification, regulates cholesterol and triglyceride levels, and increases energy levels. New research shows that DMG can function as an antioxidant and prevent free-radical damage. So, you can see how this nutrient can be a wonderful adjunct to traditional medical therapy for many different disease states.

DMG impacts the function of several key metabolic pathways. It is beneficial to blood glucose and lipid metabolism as well as liver function. DMG is a metabolic enhancer that can provide increased benefits when supplemented. DMG makes the process of metabolism quicker and more efficient. DMG improves oxygen utilization, detoxification, cell protection, immune system modulation and also enhances the healing process. It helps maintain homeostasis.

DMG is found naturally in low levels in the body, and also in certain foods, such as meat (liver), beans, seeds and grains. It is considered an intermediary metabolite, meaning that it is rapidly broken down into other substances that the body needs. The body can produce small amounts of DMG from choline and betaine, but supplementation can provide increased levels of DMG resulting in many healthful benefits for the body. DMG is built from the amino acid, glycine, and is physiologically active and important to cell metabolism. It provides methyl groups for modification, building and detoxifying many components in the body.

Biochemically, it occupies a central position in the cell's metabolic pathway, so it can produce a wide range of biological effects in the body. Here is a list of the biological activities of DMG:

It provides useful building units for biosynthesis of vitamins, hormones, neurotransmitters, antibodies, nucleic acids and other metabolically active molecules.

It improves oxygen utilization to reduce hypoxic states in the body and it removes lactic acid from muscle tissue.

It improves the immune response by increasing resistance to disease and infection.

It has antiviral, antibacterial and anti-tumor properties and modulates inflammation responses.

It aids in cardiovascular functions by reducing elevated cholesterol, blood pressure and triglyceride levels and improving circulation.

It possesses anti-cancer activity and can prevent metastases.

It enhances energy levels, endurance and muscle metabolism.

It improves mental and physical performance.

It improves neurological function and mental clarity.

It improves verbal communications and social interactions in autistic individuals.

It increases the threshold for seizures and can reduce seizures.

It improves glucose metabolism and retard cataract formation.

It aids in detoxification and enhances liver function.

Laboratory and clinical research indicates that DMG supplementation can be used effectively as a nutritional adjunct to a number of health issues:
Cardiovascular problems
Glucose metabolism
Autoimmune disorders
Allergies
Cancer/tumors
Liver diseases
Respiratory problems
Immune response deficiencies
Neurological disorders

DMG use in Veterinary Medicine

DMG has been used by veterinarians and trainers in horses and dogs. DMG is suggested for use in dogs, cats, horses and birds for performance and enhanced recovery from illness. It can be used therapeutically as an adjunct to traditional therapy for osteoarthritis, stress, seizures, allergies, heart disease, cancer, feline immunodeficiency virus (FIV), feline infectious peritonitis (FIP) and diabetes.

DMG has antifungal properties and helps fight bacterial and viral infections. It is converted to SAM-E in the body. It helps detoxify the liver. It decreases the inflammation associated with IBD (inflammatory bowel disease). It helps maintain glucose metabolism and can help prevent diabetic cataracts. DMG helps circulation and cardiovascular health.

It increases the threshold for seizures and I have personally used it to control seizures in many small exotics. In many cases, DMG alone will control seizures, and in other cases, reduced amounts of anticonvulsants will be necessary (such as phenobarbital, diazepam or phenytoin). It can be used for many neurological problems in exotic animals, such as idiopathic seizures in red lored Amazons and peach-faced lovebirds, E. cuniculi in rabbits, PDD in psittacines and hypoglycemic seizures in ferrets.

Dosage

DMG should be taken between meals, although it can be taken with food. DMG is broken down quickly and used by the body, so smaller, multiple doses are better than giving the entire dose all at once. The upper limit of dosing is extremely high; humans can take up to 6000 mg. per day without complications or risk of overdosage.

DMG comes in a liquid and the dosage is right on the label, and the dosage is also marked on the dropper which is included. Vetri-DMG Liquid is available for use in small animals and exotics. Each drop contains 5 mg of DMG.

The dosage for birds is: 1 drop per 100 grams body weight. This is given BID as a loading dose, for two weeks, then once a day. The liquid may also be used for dogs and cats: for animals:
up to 25 lbs: give 0.5 ml daily
25-50 lbs: give 1.0 ml daily
51-90 lbs: give 1.5 ml daily
91+ lbs: give 2.0 ml daily

Give dosage two times per day for the first two weeks, as a loading dosage, then give once a day, or for best results, divide dosage between a.m. and p.m.

DMG is also available in tablets for small animals. DMG is available from Vetri-Science Labs, phone number: 800-882-9993.

Cadeusus
Copyright 2006 Margaret A. Wissman, D.V.M., D.A.B.V.P.
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